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. 2014 Jun 19;8(6):e2853. doi: 10.1371/journal.pntd.0002853

Figure 1. Schedule of vaccine doses and sample collection before and after challenge.

Figure 1

Macaques were vaccinated with three (rA2/rhIL-12/alum) or four (Ad5-A2+rA2/rhIL-12/alum and DNA-A2+Ad5-A2) doses with a 21 days interval in between immunizations. The controls (i.e., rhIL-12/alum or Ad5-ASP2+rhIL-12/alum and DNA-wt+Ad5-ASP2) received the same dose schedule than the correspondent vaccine formulation. Sera were collected before initiating (T0) and 29 days after the last boost (T93), as well as 14 (T193) and 24 (T270) weeks after challenge. Clinical exams and hematological analysis was performed at day of challenge and 6, 12, 18 and 24 weeks post challenge. Histopathology and parasitism was evaluated at 6 and 24 weeks post infection.