Table 2. Genotyping results of the candidate SNPs.
location | Genotype | Cases (n = 1109 ) | Controls (n = 1275 ) | OR (95% CI)a | p | pHWE of control | |||
n | % | n | % | ||||||
miR-124-1 rs531564 | primary-miRNA | CC | 803 | 72.4 | 910 | 71.4 | 1 | 0.011 b | 0.840 |
CG | 295 | 26.6 | 331 | 26.0 | 0.99 (0.83, 1.20) | 0.952 | |||
GG | 11 | 1.0 | 34 | 2.6 | 0.61 (0.43, 0.87) | 0.005 | |||
miR-34 rs4938723 | primary-miRNA | TT | 489 | 44.1 | 569 | 44.6 | 1 | 0.033 b | 0.816 |
TC | 536 | 48.3 | 573 | 44.9 | 1.10 (0.93, 1.31) | 0.276 | |||
CC | 84 | 7.6 | 133 | 10.5 | 0.84 (0.72, 0.98) | 0.023 | |||
miR-26-1 rs7372209 | primary-miRNA | GG | 541 | 48.8 | 628 | 49.3 | 1 | 0.341b | 0.919 |
GA | 454 | 40.9 | 538 | 42.2 | 0.98 (0.83, 1.17) | 0.888 | |||
AA | 114 | 10.3 | 109 | 8.5 | 1.10 (0.95, 1.28) | 0.186 | |||
miR-27 rs895819 | precursor-miRNA | AA | 613 | 55.3 | 719 | 56.4 | 1 | 0.851b | 0.481 |
AG | 414 | 37.3 | 466 | 36.5 | 1.03 (0.87, 1.23) | 0.724 | |||
GG | 82 | 7.4 | 90 | 7.1 | 1.04 (0.89, 1.23) | 0.625 | |||
miR-218 rs11134527 | primary-miRNA | TT | 396 | 35.7 | 454 | 35.6 | 1 | 0.512b | 0.517 |
TC | 529 | 47.7 | 630 | 49.4 | 0.94 (0.78, 1.12) | 0.491 | |||
CC | 184 | 16.6 | 191 | 15.0 | 1.06 (0.93, 1.20) | 0.382 |
Adjusted for age, sex, drinking and smoking.
Chi-square test for 3 genotypes between case and control groups.