Figure 1. Isoflurane increases adenosine generation in cultured endothelial cells.

Adenosine in media from human umbilical vein endothelial cells (EA.hy926, A) or mouse glomerular endothelial cells (GENC, B) measured with high pressure liquid chromatography. Isoflurane treatment (0–2.5%) for 6 hr increased adenosine concentrations when compared to carrier gas-treated controls (N = 5). Data are presented as means ± SEM. *P<0.05 vs. carrier gas-treated controls. Error bars represent 1 SEM.