Skip to main content
. 2014 Jun 19;9(6):e99950. doi: 10.1371/journal.pone.0099950

Figure 9. Proposed mechanisms of isoflurane-mediated endothelial CD73 generation.

Figure 9

We hypothesize that isoflurane via Rho kinase activation releases endothelial microparticles containing CD73. Increased endothelial microparticle CD73 converts AMP to adenosine which produces cytoprotective effects on neighboring endothelial cells or renal epithelial cells via activation of adenosine receptors. Furthermore, we hypothesize that remote delivery of CD73 containing microparticles may provide systemic anti-inflammatory effects of isoflurane anesthesia. Abbreviations: AMP = adenosine monophosphate, CD73 = ecto-5′-nucleotidase.