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. 2014 Jun 19;9(6):e99770. doi: 10.1371/journal.pone.0099770

Figure 5. AK6 and E249 depress high frequency afferent stimulation (HFS)-induced epileptiform activity in the rat hippocampus.

Figure 5

A: Sample traces of a single PS and multiple PS (mPS) induced by a patterned HFS (see methods). B: Sample voltage traces (recorded in gap-free mode) showing that AK6 suppresses afterdischarge (downward arrowheads) immediately following HFS. C: Bar graphs summarizing the effect of AK6 on the AD frequency. D: Sample voltage traces (recorded in gap-free mode) showing that E249 suppresses SBs, referred to as stimulus train-induced bursts (STIBs, upwards arrowheads). E: Bar graphs summarizing the effect of E249 on STIBs.