. 2014 Mar 25;5(4):477–497. doi: 10.4161/viru.28595

Table 3. List of protective antigens and/or candidate vaccine molecules from Streptococcus suis.

Candidate vaccine molecules	Properties	Animal model	Year	References
EF	Extra-cellular factor	Pigs	2001	171
38 kDa	A protein of 38 kDa localized on bacterial surface and/or cell wall	Pigs	2005	104
SLY	Suilysin	Mice	2009/2013	⁹⁶^,¹⁷², and ²³⁰
MRP	Muramidase-released protein	Pigs, CD1 mice	2001, 2012	¹⁷¹ and ²³⁷
SAO	Surface antigen protein	Mice and piglets	2007	¹²¹ and ¹²²
6PGD	6-Phosphogluconate dehydrogenase (6PGD) localized on cell surface	Piglets	2009	238
Enolase	A surface-localized enzyme of central metabolism, catalyzing the dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate	Mice	2009	⁹⁶^,¹²⁹^,¹³⁰, and ¹⁴³
RfeA	RTX family exoprotein A	Mice	2009	172
ESA	Epidermal surface antigen	Mice	2009	172
IBP	Immunoglobulin G (IgG)-binding protein	Mice	2009	172
PAPI-2b	Pilus subunit	Mice	2010	125
SsPepO	A secretary immunogenic protein discovered by immuno-proteomic techniques	Mice/pigs	2011	173
HP0197	An immunogenic protein	Mice/piglets	2009	115
HP0245	in vivo-induced protein located on the cell surface	Mice	2011	239
Lmb	A surface protein	Mice	2013	240
Sat (HP0272)	Immunogenic surface protein Sat	Mice	2010	¹¹² and ¹⁷⁴