Table 3. List of protective antigens and/or candidate vaccine molecules from Streptococcus suis.
Candidate vaccine molecules | Properties | Animal model | Year | References |
---|---|---|---|---|
EF | Extra-cellular factor | Pigs | 2001 | 171 |
38 kDa | A protein of 38 kDa localized on bacterial surface and/or cell wall | Pigs | 2005 | 104 |
SLY | Suilysin | Mice | 2009/2013 | 96, 172, and 230 |
MRP | Muramidase-released protein | Pigs, CD1 mice | 2001, 2012 | 171 and 237 |
SAO | Surface antigen protein | Mice and piglets | 2007 | 121 and 122 |
6PGD | 6-Phosphogluconate dehydrogenase (6PGD) localized on cell surface | Piglets | 2009 | 238 |
Enolase | A surface-localized enzyme of central metabolism, catalyzing the dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate | Mice | 2009 | 96, 129, 130, and 143 |
RfeA | RTX family exoprotein A | Mice | 2009 | 172 |
ESA | Epidermal surface antigen | Mice | 2009 | 172 |
IBP | Immunoglobulin G (IgG)-binding protein | Mice | 2009 | 172 |
PAPI-2b | Pilus subunit | Mice | 2010 | 125 |
SsPepO | A secretary immunogenic protein discovered by immuno-proteomic techniques | Mice/pigs | 2011 | 173 |
HP0197 | An immunogenic protein | Mice/piglets | 2009 | 115 |
HP0245 | in vivo-induced protein located on the cell surface | Mice | 2011 | 239 |
Lmb | A surface protein | Mice | 2013 | 240 |
Sat (HP0272) | Immunogenic surface protein Sat | Mice | 2010 | 112 and 174 |