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. 2014 Jun 13;7:1061–1070. doi: 10.2147/OTT.S61442

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© 2014 Aref et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Human CTLs specifically kill target cells displaying HCA peptides via an HLA-A*0201 restricted manner.

Notes: T2 cells were loaded with exogenous peptides HCA519_464–472 (peptide 1), HCA519_351–359 (peptide 2) or influenza M1_58–66 (FLU) peptide for 2 hours at 37°C and then radiolabeled with Cr⁵¹ for 1 hour at 37°C. These washed target cells were incubated for 4 hours with various effectors: target ratios (50:1, 25:1 and 12:1). * denotes significant differences (P<0.05) of the experimental values from their respective control values, as typified by the responses towards the influenza peptide (A and B).

Abbreviations: CTLs, cytolytic T lymphocytes, HCA, hepatocellular carcinoma-associated antigen; HCA519, hepatocellular carcinoma-associated antigen-519; HLA-A, human leukocyte antigen-A; SD, standard deviation.