Skip to main content
. 2014 Feb 13;9(5):685–692. doi: 10.4161/epi.28151

Table 1. Distribution of age, gender, CDKN2A, pigmentation phenotype, and sun exposure variables in 64 melanoma-prone families by CMM status.

    Unaffected Individuals
(n = 122)		   CMM Cases
(n = 114)		  

P value
  N %   N %  

Age at blood draw		                
< 50   73 59.84   70 61.40    
50+   49 40.16   44 38.60   0.79
Gender                
Female   77 63.11   64 56.14    
Male   45 36.89   50 43.86   0.15
CDKN2A                
Non-Carrier   90 73.77   69 60.53    
Carrier   32 26.23   45 39.47   0.003
Dysplastic nevi                
Unaffected   71 69.61   2 2.17    
Affected   31 30.39   90 97.83   < 0.0001
Moles                
0–24   41 36.94   9 9.18    
25–99   46 41.44   23 23.47    
100+   24 21.62   66 67.35   < 0.0001
Freckles                
None/few   33 45.83   12 19.35    
Moderate   21 29.17   15 24.19    
Many   18 25.00   35 56.45   < 0.0001
Solar injury                
None/mild   77 68.75   48 48.98    
Moderate   22 19.64   27 27.55    
Severe   13 11.61   23 23.47   0.006
Tanning ability                
Tan/Little burn   59 60.82   40 46.51    
Burn/Little tan   38 39.18   46 53.49   0.07
Skin type                
Dark/medium   33 32.04   13 14.94    
Pale/fair   70 67.96   74 85.06   0.006
Eye color                
Black/brown   27 26.47   18 20.69    
Hazel   25 24.51   18 20.69    
Green/gray   14 13.73   12 13.79    
Blue   36 35.29   39 44.83   0.51
Hair color                
Black/brown   45 44.12   35 40.23    
Blonde brown/light brown   29 28.43   27 31.03    
Blonde   17 16.67   12 13.79    
Red   11 10.78   13 14.94   0.71
MC1R                
Wild type   25 27.17   3 3.85    
1 nonsynonymous variant   39 42.39   40 51.28    
2 nonsynonymous variants   28 30.43   35 44.87   0.0001

P values were obtained by comparing CMM cases to unaffected individuals using a generalized estimating equation and adjusting for familial correlation in the variance.