Table 4. Gene set analysis of the association of arsenic exposure and DNA methylation changes on biological pathways from the Kyoto Encyclopedia of Genes and Genomes (KEGG).

		Blood (unadjusted)		Blood (WBC-Adjusted)
		mean F	max F	mean F	max F
EWAS	Entire 450K Array	0.004	<0.001	0.06	< 0.001
Any Kegg	Any CpG mapped to any gene in a KEGG pathway	0.001	<0.001	0.066	0.075
Any Gene	Any CpG mapped to any gene	0.001	<0.001	0.065	0.082
hsa04950	Maturity onset diabetes of the young	0.001	<0.001	0.014	0.054
hsa04640	Hematopoietic cell lineage	<0.001	<0.001	0.023	0.023
hsa04614	Renin-angiotensin system	<0.001	<0.001	0.024	0.002
hsa04514	Cell adhesion molecules (CAMs)	<0.001	<0.001	0.028	0.036
hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	<0.001	<0.001	0.027	0.029
hsa04612	Antigen processing and presentation	<0.001	0.01	0.053	0.036
hsa04350	TGF-β signaling pathway	<0.001	<0.001	0.039	0.005
hsa05410	Hypertrophic cardiomyopathy (HCM)	<0.001	<0.001	0.04	0.023
hsa04020	Calcium signaling pathway	<0.001	<0.001	0.042	0.012
hsa05414	Dilated cardiomyopathy	<0.001	<0.001	0.05	0.024
hsa05218	Melanoma	<0.001	0.002	0.053	0.283
hsa04320	Dorso-ventral axis formation	<0.001	<0.001	0.036	0.02
hsa04920	Adipocytokine signaling pathway	<0.001	<0.001	0.05	0.026
hsa05200	Pathways in cancer	<0.001	<0.001	0.054	0.097
hsa04512	ECM-receptor interaction	<0.001	<0.001	0.077	0.007
hsa04670	Leukocyte transendothelial migration	<0.001	<0.001	0.054	0.013
hsa04810	Regulation of actin cytoskeleton	<0.001	<0.001	0.063	0.038
hsa04914	Progesterone-mediated oocyte maturation	0.001	0.001	0.054	0.039
hsa04650	Natural killer cell mediated cytotoxicity	<0.001	<0.001	0.060	0.005
hsa03320	PPAR signaling pathway	<0.001	<0.001	0.057	0.026
hsa04150	mTOR signaling pathway	0.001	0.003	0.062	0.004
hsa04510	Focal adhesion	<0.001	<0.001	0.083	0.016
hsa04520	Adherens junction	0.001	<0.001	0.051	0.135
hsa04330	Notch signaling pathway	<0.001	0.002	0.07	0.048