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. 2014 Jun 19;9(6):e100360. doi: 10.1371/journal.pone.0100360

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© 2014 Jiang et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) A total of 1 million reads (75 bases) were randomly simulated with different rates of bisulfite conversion and aligned to human (GRCh37/hg19) genome. Methy-Pipe accurately detected various simulated methylation levels at a constant mapping efficiency which is not affected by the sequence context. The H (in CHG and CHH) denotes C, T, or A. (B) Density scatter plots are plotted to measure the correlation between the MDs from Methy-Pipe and the β value from Infinium Human Methylationa450 array for CpG loci that can be integrated by both sequencing and array platforms from Placenta.