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Case/control study number consists of 50% cancer cases and 50% cancer free controls. Assuming cumulative incidence of breast cancer of 0.08 for individuals in study, α= 0.1, β = 0.2, MAF = minor allele frequency
| Subjects necessary to characterize as pathogenic | ||||
|---|---|---|---|---|
| RR | Tumor Type | MAF = 0.001 | MAF = 0.0001 | MAF = 0.00001 |
| RR = 12 | Breast | 663 | 6,544 | 65,358 |
| RR = 6 | Breast | 1,652 | 16,392 | 163,792 |
| RR = 3 | Breast | 5,491 | 54,650 | 546,238 |
| RR = 1.5 | Breast | 49,162 | 490,135 | 4,899,864 |
