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Case/control study number consists of 50% cancer cases and 50% cancer free controls. Assuming cumulative incidence of colon cancer of 0.03 for individuals in study, α= 0.1, β = 0.2, MAF = minor allele frequency
| Subjects necessary to characterize as pathogenic | ||||
|---|---|---|---|---|
| RR | Tumor Type | MAF = 0.001 | MAF = 0.0001 | MAF = 0.00001 |
| RR = 20 | Colon | 368 | 3,606 | 35,988 |
| RR = 10 | Colon | 830 | 8,204 | 81,944 |
| RR = 5 | Colon | 2,178 | 21,632 | 216,170 |
| RR = 2.5 | Colon | 8,331 | 82,959 | 829,236 |
