Table 1.
Variable | P+SSRI non-responders (n = 9) | Remitters (n = 36*) | Test | p Value |
---|---|---|---|---|
Age, Years | 43.8(8.0) | 41.1(9.0) | t=−.830 | .411 |
Duration of Current Episode, Weeks | 156.6(250.7) | 132.3(113.5) | t=.791 | .791 |
Baseline HDRS | 19.0(3.5) | 18.5(3.1) | t=−.441 | .661 |
Age of MDD Onset, Years | 28.2(8.5) | 27.8(12.1) | t=−.094 | .926 |
Baseline HAMA | 14.7(6.3) | 14.0(2.9) | t=−.456 | .650 |
Baseline BDI | 21.6(3.0) | 20.0(7.4) | t=−.611 | .544 |
CTQ Total | 40.3(10.3) | 46.4(14.6) | t=.1.173 | .247 |
Education, Years | 15.0(1.8) | 16.0(1.7) | t=1.357 | .183 |
Gender, Female/Male | 4/5 | 17/19 | χ2=.200 | .655 |
Treatment arm, CBT/sCIT | 4/5 | 19/17 | χ2=.200 | .655 |
Current anxiety disorder No/Yes | 7/2 | 26/10 | χ2=.114 | .736 |
Lifetime Substance Use Absent/Subthreshold/Threshold | 4/3/2 | 21/10/5 | χ2=.648 | .723 |
Current MDD, None/Melancholic/Atypical | 3/4/2 | 12/16/7 | χ2=.022 | .989 |
Previous Medication, No/Yes | 1/8 | 10/26 | χ2=1.083 | .298 |
Previous Psychotheraphy, No/Yes | 5/4 | 17/19 | χ2=.200 | .655 |
Lifetime PTSD, No/Yes | 9/0 | 33/3 | χ2=.804 | .370 |
Married or Cohabitating, No/Yes | 5/3 | 14/21 | χ2=1.337 | .248 |
Employed Full Time, No/Yes | 4/4 | 15/20 | χ2=.135 | .714 |
First Degree Family History, No/Yes | 3/5 | 24/11 | χ2=2.691 | .101 |
Race, White/Black/Hispanic | 8/0/0 | 26/5/4 | χ2=2.602 | .272 |
Lifetime Episodes, 1/2/3+ | 3/3/3 | 10/11/14 | χ2=.145 | .930 |
Data are mean (SD) except as noted. Included only patients with available PET scans. HDRS, Hamilton Depression Rating Scale; HAMA, Hamilton Anxiety Scale; BDI, Beck Depression Inventory; CBT, cognitive behavior therapy; sCIT, escitalopram; PTSD, Post traumatic stress disorder
Demographic and behavior data were available for all 36 remitters, PET scans were only available for 35 remitters.