Table 2.
Clinical and demographic comparisons
Parameter [±S.D.] | pHEs [n = 4] | Cirrhotic HE [n = 5] | Alcoholics [n = 4] | Controls [n = 4] |
---|---|---|---|---|
Mean age (years) | 55 [7.5] | 57 [11.6] | 53 [7.5] | 59 [11.6] |
Gender (M/F) | 3/1 | 2/3 | 3/1 | 3/1 |
Mean PMI | 22 [5.6] | 34 [19.9] | 24 [6.6] | 20 [9.5] |
Mean brain weight (g) | 1287 [86] | 1269 [124] | 1392 [52] | 1372 [135] |
Mean brain pH | 6.36 [0.20] | 6.44 [0.37] | 6.70 [0.23] | 6.61 [0.23] |
Mean Fixation period (months) | 84.5 [53.8]* | 56.8 [20.9] | 15.7 [9.5]* | 17.8 [22.5]* |
Severity of liver pathology (0,1,2,3)B | 0,0,0,4 | 0,0,0,5 | 1,1,2,0 | 1,2,0,0A |
Mean daily alcohol consumption (g/day)C,D | 211 [114.8] | 206 [87.4] | 183 [41.0] | 5 [6.2]* |
Smoking (Ever/Never)C | 3/1 | 3/2 | 3/1 | 1/2A |
Smoking (Mean pack years)C | 25.3 [22.1]A | 26.7 [25.1] | 27.5 [22.2] | 1.9 [2.8]A |
significant difference, p-value < 0.05
Data missing
liver pathology: 0 = nil or congestion, 1 = mild steatosis, 2 = severe steatosis/mild fibrosis; 3 = cirrhosis or severe inflammation
estimated from medical history and next of kin questionnaires.
calculated by mean daily consumption × 365 × years drinking [excluding periods of abstinence].