Figure 2.

WRNexo^Δ mutants are not sensitive to double-strand break-inducing agents. (A) Both WRNexo^Δ and compound heterozygous WRNexo^Δ/WRNexo^D229V mutant larvae were exposed to increasing doses of camptothecin (CPT) and adult survival was determined. n = 3 trials for each dose. Brca2^KO data were originally reported in Thomas et al. (2013). (B) WRNexo^Δ and Blm^N1 mutant larvae were exposed to increasing doses of bleomycin and adult survival was calculated. n = 3.