Skip to main content
. 2014 Mar 18;197(2):667–684. doi: 10.1534/genetics.114.161349

Figure 2.

Figure 2

Conserved pair of hydrophobic/basic residues mediate ciliary targeting of a subset of GPCRs in AWB and ASK. (A) Alignment of C-terminal sequences of Rhodopsin and Smoothened with STR-1, STR-44, STR-163, SRSX-3, SRU-38, and SRD-23. The hydrophobic/basic residue pairs and the VxPx motif mutated to alanines are shaded. (B–E) Localization patterns of indicated GPCR::GFP fusion proteins in AWB (B–D) or ASK (E). Note cell membrane localization of SRSX-3mut::GFP in D. White arrows indicate cilia; white arrowheads indicate dendrites; yellow arrowheads indicate cell bodies. Lateral views. Bar, 10 μm.