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Chemical structures of Den-RGD and Den-PEG. The cyclic peptide cRGDyK, Gd3+-DTPA, IR783, and rhodamine were functionalized into the fifth generation PAMAM dendrimer to synthesize the ανβ3 integrin-targeted nanoprobe Den-RGD. The control nanoprobe Den-PEG, which had a similar chemical structure to Den-RGD but without the cyclic peptide targeting domain, was prepared.
