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. 2014 Jun 7;4(8):823–833. doi: 10.7150/thno.8696

Figure 2.

Figure 2

Figure 2

Ex Vivo and In Vivo Screening Assay of Fluorophores for Nerve-Specificity. A) Nerve-specific fluorescence intensity was determined using staining of human sural nerve cut in cross section and incubated with 100 µM of each fluorophore. Ep = epineurium; F = nerve fascicle. Scale bars = 200 µm. The partition coefficient (logD at pH 7.4) was calculated using JChem calculator plugins. B) In vivo nerve-specific fluorescence in the rat brachial plexus (BP, top rows) and sciatic nerve (SN, bottom rows) 4 h post-injection. Arrowheads indicate fluorescence signals in nerve tissue. SG = salivary gland. Scale bars = 1 cm. All NIR fluorescence images have identical exposure and normalizations.