Table 1.

Characters of different ATCT in solid tumors.

Type of ATCT	Characters	Advantages	Disadvantages	Comments
LAK cells	Non-specific. Non-MHC-restricted	Modest efficacy in melanoma, RCC, and glioma through systematic administration or intralesional injection	High toxicity. Limited expansion in vitro Low cytotoxicity	Almost abandoned
CIK cells	Non-specific. Non-MHC-restricted	Improved cytotoxicity VS LAKs. Low toxicity	The definite conclusion about the clinical efficacy of CIKs is unclear	Potential applicability in various solid tumors
TILs	Specific	Most effective treatment for metastatic melanoma	Candidature only accepted when the tumor is resectable Requirement of immunodepleting preparation	Limited application in other solid tumors
TCR-T cells	Specific MHC-restricted	High avidity to tumor cells Long-lasting responses	Limited identified TAAs “On-target, off-organ” effects	Potential applicability in various solid tumors
CAR-T cells	Specific Non-MHC-restricted	Wide range of potential target TAAs High avidity to tumor cells Long-lasting responses	“On-target, off-organ” effects	Potential applicability in various solid tumors