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CCN2 expression drives miR-21, which drives CCN2 expression in vitro. CCN2, miR-21 or collagen α1(I) expression levels as demonstrated by qRT-PCR in activated PSC (P5) transfected with CCN2 siRNA +/− pre-miR-21 for a 24 h or b 48 h. (*p < 0.05, **p < 0.001)
