Figure 7. Possible mechanism by which the PRIP/protein-phosphatase complex mediates lipolysis.

Lipolysis in adipocytes is mediated by the activation of a PKA-mediated pathway. The process is regulated by lipases (HSL and ATGL) and other modulatory proteins, including perilipin, CGI-58, PP2A, and PRIP (see Discussion). The disappearance of the dotted line represents postulated situations in PRIP-DKO mice. TAG, triacylglycerol; FFA, free fatty acid; P, phosphate group; PKA, protein kinase A; HSL, hormone-sensitive lipase; PRIP, phospholipase C-related catalytically inactive protein; PP2A, protein phosphatase 2A; CGI-58, comparative gene identification 58 (abhydrolase domain-containing protein 5).