Table 2.

MicroRNAs associated with Toll-like receptor signaling pathways, downregulated by 5-fold or greater in HepG2.2.15 than in HepG2

MicroRNAs	Genomic location	Fold changes	Description of target molecules/pathways	Ref.
let-7e-5p	19q13.33	-7.29	Akt1 activated by TLR4-ligand LPS, positively regulated let-7e	[52]
let-7a-3p	9q22.32	-11.44	Repression of let-7 family relieves IL-6 and IL-10 mRNAs from negative post-transcriptional control in TLR4 signaling pathway	[53]
	11q24.1
	22q13.31
let-7i-3p	12q14.1	-11.57	let-7i regulates Toll-like receptor 4 expression	[54]
let-7a-5p	9q22.32 11q24.1 22q13.31	-11.96	Repression of let-7 family relieves IL-6 and IL-10 mRNAs from negative post-transcriptional control in TLR4 signaling pathway	[53]
let-7d-5p	9q22.32	-14.03	Repression of let-7 family relieves IL-6 and IL-10 mRNAs from negative post-transcriptional control in TLR4 signaling pathway	[53]
let-7i-5p	12q14.1	-15.10	let-7i regulates Toll-like receptor 4 expression	[54,55]
miR-132-3p	17p13.3	-18.18	TNF receptor-associated factor 6 and IL-1 receptor-associated kinase 1	[56]
let-7b-5p	22q13.31	-116.31	let-7b activates TLR 7	[56]

Genomic location was analyzed using GeneCards (http://gene4.weizmann.ac.il/). TLR: Toll-like receptor.