Table 1.
Gene variants associated with fatty liver disease identified by Genome Wide Association Studies
Ref. | Gene | Polymorphisms | Chromosome | Number of subjects studied |
Romeo et al[35] | PNPLA3 | rs738409 | 22 | 3383 |
Speliotes et al[71] | GCKR | rs1260326 | 2 | 7176 |
Petersen et al[60] | APOC3 | rs2854116 | 11 | 258 |
rs2854117 | ||||
Speliotes et al[71] | NCAN | rs2228603 | 19 | 7176 |
Speliotes et al[71] | LYPLAL1 | rs12137855 | 1 | 7176 |
Speliotes et al[71] | PPP1R3B | rs4240624 | 8 | 7176 |
Adams et al[73] | GC | rs222054 | 4 | 928 |
Adams et al[73] | LCP1 | rs7324845 | 13 | 928 |
Adams et al[73] | SLC38A8 | rs11864146 | 16 | 928 |
Adams et al[73] | LPPR4 | rs12743824 | 1 | 928 |
Kitamoto et al[72] | SAMM50 | rs2143571 | 22 | 1326 |
Kitamoto et al[72] | PARVB | rs6006473 | 22 | 1326 |
rs5764455 | ||||
rs6006611 | ||||
Chalasani et al[66] | FDFT1 | rs2645424 | 8 | 236 |