Table 2.
Basal characteristics and results of blood chemistry
| Treatment group | BDL+/Rapa- (n = 4) | BDL+/Rapa+ (n = 7) | BDL+/Rapa++ (n = 7) | BDL-/Rapa- (n = 4) | P value1 |
| TBWt (g) | 323.25 ± 85.84 | 351.28 ± 55.42 | 338.57 ± 21.16 | 276.25 ± 15.9 | 0.136 |
| Liver Wt (g) | 20.49 ± 2.68a | 23.55 ± 4.90a | 21.53 ± 3.10a | 10.85 ± 0.38 | < 0.0001 |
| Liver Wt/TBWt | 0.065 ± 0.011ac | 0.069 ± 0.017a | 0.064 ± 0.010ac | 0.040 ± 0.003c | 0.010 |
| AST (U/L) | 254.50 ± 143.79 | 244.43 ± 97.56 | 293.57 ± 89.67 | 86.75 ± 10.69 | 0.023 |
| ALT (U/L) | 47.00 ± 17.87 | 50.86 ± 21.97 | 52.00 ± 17.58 | 34.25 ± 2.63 | 0.429 |
| TB (mg/dL) | 9.15 ± 2.16a | 8.74 ± 0.92a | 11.17 ± 2.11a | 0.50 ± 0.14 | < 0.0001 |
| TP (g/dL) | 5.48 ± 1.28 | 5.37 ± 0.33 | 5.74 ± 0.61 | 5.48 ± 0.38 | 0.773 |
| Alb (g/dL) | 2.65 ± 0.85a | 2.81 ± 0.41a | 3.43 ± 0.43a | 3.83 ± 0.33 | 0.008 |
Statistical significances were tested by one-way analysis of variances among groups and statistically significant results are indicated by P values.
P < 0.05 vs BDL-/Rapa-;
P < 0.05 vs BDL+/Rapa+ based on Scheffe multiple comparison test. Basal characteristics and results of blood chemistry in bile duct ligation (BDL+/Rapa-), bile duct ligation with rapamycin (BDL+/Rapa+, BDL+/Rapa++) and sham-operated (BDL-/Rapa-) groups. Each values indicate mean ± SD. TBWt: Total body weight; Wt: Weight; TP: Total protein; Alb: Abumin; AST: Aspartate transaminase; ALT: Alanine transaminase; TB: Total bilirubin; Rapa: Rapamycin; Rapa+: Rat administered rapamycin for 28 d from the 14th day post-BDL; Rapa++: Rat administered rapamycin for 28 d beginning the first day post-BDL.