Figure 4.

CAR(SV3) differentially transactivates promoter reporter genes COS1 cells were co-transfected with enhancer/promoter reporter gene plasmids and expression plasmids encoding CAR isoforms, as indicated. The columns show the mean activation factors (± S.D.) of the respective reporter genes by the indicated CAR isoforms. The activity of each reporter in the presence of empty expression vector pcDNA3 was designated as 1. Statistically significant differences are indicated by asterisks (***, p < 0.001).