Figure 4.

Functional classification of gene ontologies overrepresented among the large ATL clones. Functional categories significantly overrepresented among the random, AC, ATL small, intermediate, and large ATL clones as analyzed by Ingenuity software using the Ingenuity Pathways Knowledge Base (IPKB) gene population as baseline. Horizontal bars are only visible where there was a statistical overrepresentation of the pathway compared with the IPKB. Because there were no overrepresented pathways involving the random integration sites or intermediate-abundance clones in ATL cases, the bars are not visible. The vertical yellow threshold represents the line of statistical significance (P < .05) after correction (Benjamini-Hochberg) for multiple testing. The numbers of searchable genes for comparison with the IPKB were random (n = 96 706), AC (n = 5679), ATL small (n = 1628), ATL intermediate (n = 87), or ATL large (acute n = 141, lymphoma n = 31, chronic and smoldering n = 38).