Figure 5.

Preferential survival of HTLV-1 in vivo in chromosomes 13, 14, 15, and 21. The proportion of unique integration sites (UIS) per chromosome is shown for 2 independent AC data sets (Kumamoto and Kagoshima) and the small clones in ATL cases. The yellow line shows the frequency of sites in the random data set. There were an increased number of integrations in chromosomes 13, 14, 15, and 21 in the clones of asymptomatic carriers and small clones in ATL cases compared with random. The bias remained in chromosomes 13 and 15 when compared with a previously reported data set⁶ of integration sites from Jurkat cells infected in vitro with HTLV-1.