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. 2014 Jun 20;4:5382. doi: 10.1038/srep05382

Figure 5. Autophagy leads to chemoresistance through the downregulation of Bad and Bim in HCC cells.

Figure 5

(A). The mRNA levels of Bad and Bim in the SMMC-7721 and HepG2 cells, which were incubated under normal or LH conditions in the presence or absence of CQ or 3-MA or with the knock down of Atg5 or Atg7, were detected via q-PCR. The data represent the mean ± SD based on three independent experiments. ** p < 0.01. (B). The expression levels of the two pro-apoptotic proteins were analyzed by western blotting, and the experiments were repeated at least three times.