Fig. 7.
Single-parameter modifications enable repetitive burst firing in the murine TC neuron model. A: hyperpolarizing current injection (top trace) fails to elicit repetitive bursts (bottom voltage trace) when the model is set to the default parameters that reproduce the steady-state conductance of murine TC neurons. B–F: repetitive burst firing elicited by hyperpolarization after increase of pT from 5 × 10−5 to 8 × 10−5 cm/s (B), after a global negative shift of the mT gate of −2 mV (C), after a global positive shift of the hT gate of +3 mV (D), after a decrease of ḡA from 5.5 × 10−3 to 2.0 × 10−3 S/cm2 (E), and after an increase of ḡNaP from 5.5 × 10−6 to 1.5 × 10−5 S/cm2 (F). G: repetitive burst firing elicited by depolarization after an increase of ḡKir from 2.0 × 10−5 to 1.0 × 10−4 S/cm2. Voltage traces in A–F were obtained by simulating negative current injection of −15 pA. Voltage trace in G was obtained by simulating positive current injection of +10 pA.