Table 3.

Angiogenic genes that are differentially expressed in the A2780 wild-type and mutant TP53 ovarian cancer cell lines and after treatment with hypoxia.

Gene symbol	Gene name	Function	Probe	p-Value	Adjusted p-value	Log2 fold change	Fold change
GENES UPREGULATED IN MUTANT A2780 TP53 CELLS LINES COMPARED TO WILD-TYPE A2780 TP53 CELL LINES
MMP10	Matrix metallopeptidase 10 (stromelysin 2)	ECM degradation	205680_at	<0.001	0.004	2.4	5.3
FGF20	Fibroblast growth factor 20	Neurotrophic factor	220394_at	<0.001	<0.001	1.5	2.8
ADAMTS1	A disintegrin and metalloproteinase with thrombospondin motif 1	Anti-angiogenic activity, ECM remodeling	222162_s_at	<0.001	<0.001	1.5	2.8
EFNB2	Ephrin B2	Endothelial cell adhesion	202668_at	0.001	0.27	1.2	2.3
F2R	Coagulation factor 2 (thrombin) receptor	G-protein coupled receptor, mediates activation of endothelial cells	203989_x_at	0.006	1	1.0	2.0
GENES UPREGULATED IN WILD-TYPE A2780 TP53 CELLS LINES COMPARED TO MUTANT A2780 TP53 CELL LINES
HIF1A	Hypoxia inducible factor 1	Regulates cell response to hypoxia	200989_at	<0.001	0.09	1.2	2.3
VEGFC	Vascular endothelial growth factor-C	Growth factor, angiogenesis	209946_at	0.001	0.2	1.3	2.5
ANGPTL4	Angiopoietin-like 4	Inhibits vascular growth, tumor cell invasion	221009_s_at	0.02	1	1.1	2.1
GENES UPREGULATED BY HYPOXIA vs. CONTROL
VEGFA	Vascular endothelial growth factor-A	Growth factor, angiogenesis	211527_x_at	0.002	0.9	1.6	3.0
			212171_x_at	0.003	1	1.2	2.3
			210513_s_at	0.003	1	1.4	2.6
			210512_s_at	0.001	0.4	1.8	3.5
ANGPTL4	Angiopoietin-like 4	Inhibits vascular growth, tumor cell invasion	221009_s_at	0.009	1	1.5	2.8
EFNA3	Ephrin A3	Endothelial cell migration and adhesion	210132_at	0.002	0.8	1.1	2.1