Table 2.
Apolipoprotein levels by concurrent albuminuria status. Data are shown as mean ± standard deviation for the entire cohort as well as stratified by males and females.
| Lipoprotein | All Subjects | Male Subjects | Female Subjects | ||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| Normal (n=341) | Micro (n=50) | Macro (n=45) | Normal (n=214) | Micro (n=33) | Macro (n=35) | Normal (n=127) | Micro (n=17) | Macro (n=10) | |
| Apolipoprotein-defined lipoprotein subclasses | |||||||||
| Lp-B mg ApoB/dl | 36.0 ± 9.6 | 36.6 ±11.8 | 43.6 ± 12.3† | 36.6 ± 10.0 | 37.8 ± 12.3 | 44.2 ± 12.2† | 34.8 ± 8.9 | 34.1 ± 10.7 | 41.6 ± 13.2† |
| Lp-B:C mg ApoB/dl | 11.8 ± 3.9 | 11.7 ± 3.6 | 13.4 ± 3.6† | 12.1 ± 3.9 | 12.0 ± 3.6 | 13.8 ± 3.7 | 11.3 ± 3.9 | 10.9 ± 3.5 | 11.8 ± 2.4 |
| Lp-A-I mg A-I/dl | 39.0 ± 8.0 | 38.4 ± 8.6 | 40.8 ± 6.7 | 38.7 ± 7.6 | 36.9 ± 7.9 | 40.4 ± 6.9 | 39.6 ± 8.5 | 41.1 ± 9.4 | 42.2 ± 5.9 |
| Lp-A-I:A-II mg ApoA-I/dl | 104 ± 23 | 99 ± 25 | 102 ± 29 | 102 ± 23 | 92.2 ± 20.1 | 98.4 ± 29.3 | 108 ± 23 | 113 ± 28 | 112 ± 27 |
| Lp-A-II:B:C:D:E mg ApoB/dl | 13.1 ± 4.6 | 13.9 ± 4.7 | 14.0 ± 4.4 | 12.9 ± 4.5 | 14.4 ± 4.6 | 14.3 ± 4.6 | 13.4 ± 4.7 | 13.3 ± 4.9 | 13.3 ± 3.7 |
| Lp-B:E + Lp-B:C:E mg ApoB/dl) | 12.5 ± 5.3 | 11.4 ± 4.3 | 11.5 ± 3.3 | 12.3 ± 5.8 | 11.2 ± 4.2 | 11.3 ± 3.3 | 12.7 ± 4.3 | 11.9 ± 3.3 | 11.9 ± 3.3 |
| Individual Apolipoproteins | |||||||||
| ApoB mg/dl | 73.1 ± 16.9 | 73.4 ±18.3 | 82.4 ± 16.7† | 73.6 ± 17.2 | 75.1 ± 18.8 | 83.5 ± 17.0† | 72.3 ± 16.3 | 70.0 ± 17.3 | 78.6 ± 15.8 |
| ApoA-I mg/dl | 143 ± 30 | 138 ± 32 | 142 ± 33 | 140 ± 29 | 129 ± 26 | 138 ± 33 | 148 ± 30 | 154 ± 36 | 154 ± 30.8 |
| ApoA-II mg/dl | 36.3 ± 11.7 | 32.3 ± 9.1 | 29.4 ± 9.5 | 36.2 ± 11.4 | 29.6 ± 6.4 | 29.6 ± 8.9 | 36.5 ± 12.2 | 37.5 ± 11.3 | 28.9 ± 12.1 |
| ApoE mg/dl | 4.4 ± 1.0 | 4.2 ± 0.8 | 4.0 ± 0.8 | 4.4 ± 1.0 | 4.1 ± 0.7 | 4.1 ± 0.7 | 4.3 ± 0.9 | 4.4 ± 1.1 | 3.6 ± 0.8† |
| ApoC-III mg/dl | 9.5 ± 3.5 | 9.7 ± 2.8 | 12.8 ± 4.5† | 9.3 ± 3.5 | 9.4 ± 2.7 | 13.3 ± 4.8† | 9.9 ± 3.4 | 10.4 ± 3.0 | 11.0 ± 2.5 |
| ApoC-IIIHP mg/dl | 2.6 ± 1.5 | 2.8 ± 1.0 | 3.7 ± 1.5† | 2.6 ± 1.4 | 2.9 ± 1.1 | 3.9 ± 1.5† | 2.5 ± 1.7 | 2.7 ± 0.9 | 2.8 ± 0.8 |
| ApoC-IIIHS mg/dl | 6.9 ± 2.2 | 6.8 ± 2.2 | 8.9 ± 3.0† | 6.6 ± 2.3 | 6.4 ± 1.9 | 9.2 ± 3.3† | 7.3 ± 2.2 | 7.6 ± 2.6 | 8.0 ± 1.7 |
| ApoC-III Ratio (HS/HP) | 2.9 ± 0.9 | 2.6 ± 0.9 | 2.5 ± 0.6 | 2.8 ± 0.9 | 2.4 ± 0.7 | 2.4 ± 0.5 | 3.2 ± 0.9 | 3.0 ± 1.1 | 2.9 ± 0.7 |
Boldface: P<0.05 vs. Normal;
†
P<0.05 vs. Microalbuminuria