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AM3506 was covalently docked to the catalytic Ser241 of rFAAH in the acyl chain binding channel. There is significant hydrogen bonding with the oxyanion hole (formed by the backbone of Ile238, Gly239, Gly240, and Ser241), and also with the backbone carbonyl of Thr488. Hydrogen bonds are denoted by a blue dashed line, and the surface of the binding channels is shown in gray.12
