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. 2014 May 23;15:27. doi: 10.1186/2050-6511-15-27

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Copyright © 2014 Le et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Increased uridine salvage protects liver against tamoxifen-induced lipid accumulation. (A) CARS images of liver tissues of wildtype C57BL/6J and transgenic UPase1^−/−and UPase1-TG mice as a function of tamoxifen treatment. (B) Liver lipid level determined with CARS image analysis. (C) Liver triacylglyceride (TAG) levels determined with biochemical assays. Error bars are standard deviation values across 9 mice analyzed per animal group. Single asterisk (black) indicates p-value < 0.05 versus untreated control mice. Double asterisks (gray) indicate p-value < 0.05 versus C57BL/6J mice treated with tamoxifen.