Table 1.
Radiological–pathological correlative studies: colorectal cancer
| Tumour type | Perfusion CT parameter/method | Pathological correlate/method | Findings | Study |
|---|---|---|---|---|
| Angiogenesis | ||||
| Colorectal, n = 23 | Blood volume Permeability surface Whole tumour cross-sectional area Johnson–Wilson 1 s interval Limited coverage | CD34 Random field | Moderate correlations BV: r = 0.59a, p = 0.002 PS: r = 0.46a, p = 0.03 with CD34 expression | Goh et al23 |
| Colorectal, n = 29 | Blood flow Blood volume Permeability Surface Two selected areas: Luminal and invasive edge Johnson–Wilson 1 s interval Limited coverage | Factor VIII CD105 Focused region | Variable correlations, some significant for BV and PS: BF: r = 0.05 to 0.19; p = 0.98 to 0.32 BV: r = 0.02 to 0.55a; p = 0.91 to 0.003a PS: r = 0.09 to 0.43a; p = 0.96 to 0.023a | Dighe et al24 |
| Colorectal, n = 37 | Perfusion Whole tumour cross-sectional area Slope method 2 s interval Limited coverage | CD34 Hot spot (3) | No correlation between perfusion and CD34 r = 0.18, p = 0.29 Decrease in perfusion and CD34 expression with stage | Li et al25 |
| Colorectal, n = 32 | Blood flow Blood volume Permeability surface Whole tumour cross-sectional area Johnson–Wilson 1 s interval Limited coverage | CD34 Hot spot (3) | No correlations with CD34 BF: r = −0.14, p > 0.45 BV: r = 0.11, p > 0.51 PS: r = 0.28, p > 0.12 | Feng et al26 |
| Colorectal, n = 27 | Blood flow Blood volume Permeability surface Whole tumour cross-sectional area Johnson–Wilson 1 s interval Limited coverage | CD34 Hotspot (3) | No correlations with CD34 | Kim et al27 |
BF, regional blood flow; BV, regional blood volume; PS, permeability surface area product.
a
Significant correlations.