Table 2.

Kinetic models used for perfusion CT analysis

Kinetic model	Compartments	Parameter measured	Assumptions
Maximum slope	Single	BF	No venous outflow
Johnson–Wilson	Dual	BF, BV, MTT, PS	Constrained IRF
Patlak	Dual	EF, BV	One way transfer Well-mixed compartments
Distributed parameter	Dual	BF, BV, PS, Ve	Constrained IRF

BF, regional blood flow; BV, regional blood volume; EF, extraction fraction; IRF, impulse residual function; MTT, mean transit time; PS, permeability surface area product, Ve, extravascular extracellular volume.