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. 2014 Jan 31;87(1035):20130626. doi: 10.1259/bjr.20130626

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© 2014 The Authors. Published by the British Institute of Radiology

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Figure 4. — Tumour control probability (TCP) vs biological effective dose (BED) for different stereotactic body radiation therapy (SBRT) and charged particle therapy trials for non–small cell lung cancer (NSCLC). The red curve represents the fit to the X-ray SBRT data as reported in Mehta et al³³ using the common linear–quadratic formula where d is the dose given in every fraction, n the number of fractions, and α/β = 8.6 for NSCLC. Data points are calculated from published trials with protons or C-ions.^43–46 The number of fractions is shown next to the high BED C-ions data points. The single-fraction C-ion data point with the highest BED is described in Tsujii and Kamada,⁴⁶ while the highest TCP has been achieved at Tsukuba University, Ibaraki, Japan, in a trial on 58 (T1/T2, 30/28) patients treated with 66 Gy(RBE)/10 fractions for peripherally located and 72.6 Gy(RBE)/22 fractions for centrally located tumours.⁴² BED for CPT was calculated using the formula above with d in Gy(RBE) as reported in the publications and the same α/β ratio as for X-rays.

Inline graphic — Tumour control probability (TCP) vs biological effective dose (BED) for different stereotactic body radiation therapy (SBRT) and charged particle therapy trials for non–small cell lung cancer (NSCLC). The red curve represents the fit to the X-ray SBRT data as reported in Mehta et al³³ using the common linear–quadratic formula where d is the dose given in every fraction, n the number of fractions, and α/β = 8.6 for NSCLC. Data points are calculated from published trials with protons or C-ions.^43–46 The number of fractions is shown next to the high BED C-ions data points. The single-fraction C-ion data point with the highest BED is described in Tsujii and Kamada,⁴⁶ while the highest TCP has been achieved at Tsukuba University, Ibaraki, Japan, in a trial on 58 (T1/T2, 30/28) patients treated with 66 Gy(RBE)/10 fractions for peripherally located and 72.6 Gy(RBE)/22 fractions for centrally located tumours.⁴² BED for CPT was calculated using the formula above with d in Gy(RBE) as reported in the publications and the same α/β ratio as for X-rays.