FIGURE 2.

Schematic of potential environmental influence on adaptation of the host and the microbiome. Adaptations following a transition from the regular environment (light yellow) to a stressful novel environment (pink) are represented as matching of colors and shapes. Prior to the transition, the host and its microbiome are adapted to the environment (same color) and to one another (matched patterns). Shortly after the transition, the host is only mildly changed while the microbiome is considerably more adapted to the new environment (closer in color to the new environment). This difference in responsiveness disrupts the compatibility between the host and its microbiome (unmatched patterns). With time, the host and its microbiome become progressively more adapted to the environment and to one another.