Table 7.
Effect of Serum on KEGG Pathways in Primary and Immortalized Human Meibomian Gland Epithelial Cells
|
Ontology |
Undifferentiated vs. Serum |
SFM vs. Serum |
||||||
|
Pri Genes |
Pri z-Score |
Imm Genes |
Imm z-Score |
Pri Genes |
Pri z-Score |
Imm Genes |
Imm z-Score |
|
| Upregulation | ||||||||
| Lysosome | 35 | 6.5 | 31 | 5.96 | 21 | 4.29 | 17 | 2.29 |
| p53 signaling pathway | 18 | 4.15 | 19 | 5.05 | 12 | 3.26 | 16 | 4.51 |
| Phagosome | 37 | 5.54 | 31 | 4.57 | 25 | 4.45 | 26 | 4.02 |
| Downregulation | ||||||||
| Aminoacyl-tRNA biosynthesis | 12 | 3.1 | 17 | 4.96 | 11 | 3.58 | 7 | 2.82 |
| Cell cycle | 36 | 5.3 | 51 | 8.51 | 24 | 3.43 | 21 | 4.83 |
| Ribosome | 69 | 18.22 | 50 | 11.32 | 74 | 23.08 | 31 | 11.08 |
| RNA transport | 51 | 7.58 | 57 | 8.19 | 40 | 6.71 | 17 | 2.45 |
| Steroid biosynthesis | 10 | 5.04 | 10 | 4.66 | 6 | 3.05 | 6 | 4.43 |
Selected ontologies were chosen after analyses of nontransformed data. Data are reported for designated ontologies with ≥6 genes.