Table 2. Functional characteristics of 35-fold h-β2AR overexpressing mice.
| ECHO
|
CATH
|
|||||||
|---|---|---|---|---|---|---|---|---|
| Mice | LVEDD, mm | LVESD, mm | FS, % | HR, bpm | Vcf, cps | LVP, mmHg | HR, bpm | +dp/dt, mmHg/sec |
| β2AR-35 | 3.2 ± 0.04 | 1.4 ± 0.04 | 57 ± 1 | 572 ± 14 | 12.3 ± 1 | 102 ± 1 | 486 ± 5 | 15,254 ± 64 |
| Q72L/β2—35 | 3.5 ± 0.12 | 1.6 ± 0.09 | 55 ± 1.4 | 534 ± 29 | 11.4 ± 1 | 112 ± 1 | 418 ± 8 | 14,483 ± 228 |
| S27N/β2—35 | 3.2 ± 0.06 | 1.5 ± 0.06 | 49 ± 3* | 549 ± 21 | 10.8 ± 0.3 | 101 ± 1 | 433 ± 5 | 12,852 ± 99* |
Mice (n = 4—9) expressed h-βAR alone (β2AR-35) and with Rab4 activation (Q72L) or inhibition (S27N). ECHO, echocardiogram. CATH, catheterization-derived hemodynamics; LVEDD, left ventricular diastolic dimensions; LVESD, left ventricular systolic dimensions; FS, fractional shortening; HR, heart rate; LVP, peak left ventricular systolic pressure. bpm, beats per minute. cps, circumferences per second.
*
P < 0.05 versus h-β2AR-35 by ANOVA