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. 2014 Feb;219(2):138–148. doi: 10.1016/j.imbio.2013.08.012

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© 2013 Elsevier GmbH.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).

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Fig. 7 — Effects of probiotics on DC-induced intracellular production of IL-12 and IL-10 by T cells.

T cells in the MLR culture were identified by staining with anti-CD3. Data are mean ± SE for n = 8 samples from each group. Data were normalised by the Johnson Transformation. There was a significant effect of age (P < 0.05) on expression of IL-12 and IL-10, and treatment (P < 0.05) on IL-12 on young T cells and IL-10 on young and older T cells (two-way ANOVA). Significant differences are denoted as ^NP < 0.05 relative to the no-DC control for T cells within the same age group; ^DP < 0.05 relative to DC-stimulated T cells (without LPS/probiotics) within the same age group; ^TP < 0.01 relative to T cells from older subjects with the same treatment; ^IP < 0.01relative to B. infantis 52486 for the same age group of DCs within the same age group of T cells; ^BP < 0.05 relative to B. infantis 52486 and L.GG for the same age group of DCs within the same age group of T cells (post hoc tests with Bonferroni correction).