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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Biochemistry (Mosc). 2013 Nov;78(11):1228–1237. doi: 10.1134/S0006297913110035

Fig. 2.

Fig. 2

Scheme of the impact of MC1R on development of melanoma. MC1R can affect the microphthalmia-associated transcription factor via protein kinase A (PKA), as well as via oncogenic signaling pathway RAS/RAF/MEK/ERK by Src-dependent c-KIT activation [69]. Additionally, MC1R promotes melanoma cell migration due to enhancement of syndecane-2 (Sdc2) expression [67].