Table 1.

Constructions for delivery into melanoma cells based on natural α-MSH

Name, composition	Type	Active principle	Reference
DAB389-MSH	recombinant	diphtheria toxin ADP-ribosyltransferase	[20, 77, 78]
α-MSH-melphalan	synthetic	melphalan	[79, 80]
α-MSH-HPMA-copolymer-doxorubicin	synthetic	doxorubicin	[81]
Liposomes with lipopeptide MSH-C4A2	synthetic	various	[82]
HGM–pCH110-17m–pLyP101	recombinant/synthetic	delivered gene	[83]
Modular nanotransporter DTox-HMP-NLS-MSH	recombinant/synthetic	photosensitizers	[84–87]
Nanoparticles containing PLL and PGA-MSH	synthetic	delivered gene	[88]
HFt-MSH	recombinant/synthetic	fluorophores for diagnostics	[89]

Note: DAB₃₈₉-MSH, recombinant protein with ligand domain of diphtheria toxin substituted with α-MSH; HPMA, N-(2-hydroxypropyl) methacrylamide; MSH-C4A2, α-MSH with two aliphatic chains (C16) connected via aspartate and tetramethylene bridge; HGM, GAL4 DNA-binding domain and α-MSH chimeric protein; pCH110-17m, plasmid with GAL4-binding site; pLy101, conjugate of polylysine with nuclear localization signal peptide; DTox-HMP-NLS-MSH, nanotransporter containing translocating domain of diphtheria toxin, E. coli hemoglobin-like protein, optimized large T-ag SV40 virus nuclear localization signal, and α-MSH; PLL, polylysine; PGA, polyglycolic acid; HFt, human ferritin.