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PNA disrupts estrous cyclicity in adulthood. (A) Representative estrous cycles in control (Upper), PNA, and PNA plus flutamide mice (Lower). Arrow indicates time flutamide treatment was begun. (B) Percent of days spent in each estrous cycle stage (E, estrus; D, diestrus; P, proestrus) in PNA, control, and PNA plus flutamide mice. *, P < 0.05 versus control.
