Table 1.
Patient and transplant characteristics of race matched and mismatched donors
| Donor race/ethnicity matched (N=713) N (%) |
Donor race/ethnicity mismatched (N=145) N (%) |
P | |
|---|---|---|---|
| Recipient race | < .01 | ||
| Caucasian | 675 (95) | 68 (47) | |
| Race/Ethnic minority | 38 (5) | 77 (53) | |
| African American | 9 (1) | 19 (13) | |
| Hispanic | 9 (1) | 16 (11) | |
| American Indian | 0 (0) | 5 (3) | |
| Asian | 17 (2) | 18 (12) | |
| Mixed | 3 (0) | 19 (13) | |
| Sex | .37 | ||
| Male | 427 (60) | 81 (56) | |
| Female | 286 (40) | 64 (44) | |
| Age | < .01 | ||
| < 18 years | 381 (53) | 95 (65) | |
| ≥ 18 | 332 (47) | 50 (34) | |
| Karnofsky/Lansky Score | .99 | ||
| < 80 | 41 (6) | 7 (5) | |
| 80 | 89 (12) | 19 (13) | |
| 90 | 258 (36) | 51 (35) | |
| 100 | 256 (36) | 53 (37) | |
| Unknown | 69 (10) | 15 (10) | |
| Diagnosis | .02 | ||
| Malignant | 464 (65) | 79 (54) | |
| Non-malignant | 249 (35) | 66 (45) | |
| Malignant Disease Risk | .79 | ||
| High Risk | 210 (45) | 37 (47) | |
| Standard Risk | 254 (55) | 42 (53) | |
| Malignant diagnosis category | .08 | ||
| AML, ALL, MDS | 302 (65) | 49 (62) | |
| Myeloproliferative, CML | 71 (15) | 16 (20) | |
| NHL, Hodgkins, CLL | 68 (15) | 6 (8) | |
| Other malignant disease | 23 (5) | 8 (10) | |
| Donor relation + HLA match2 | < .01 | ||
| URD well matched | 120 (17) | 19 (13) | |
| URD partially matched | 114 (16) | 15 (10) | |
| URD mismatched | 85 (12) | 29 (20) | |
| UCB 5/6 or 6/6 locus matched | 266 (37) | 39 (27) | |
| UCB 4/6 | 126 (18) | 43 (30) | |
| CMV serostatus | .02 | ||
| R+ | 321 (45) | 80 (55) | |
| R-/D+ | 67 (9) | 17 (12) | |
| R-/D- | 313 (44) | 45 (31) | |
| Unknown | 12 (2) | 3 (2) | |
| Transplant Year | .23 | ||
| 1995-1999 | 225 (32) | 46 (32) | |
| 2000-2004 | 225 (32) | 55 (38) | |
| 2005-2010 | 263 (37) | 44 (30) | |
| Conditioning Intensity | .02 | ||
| Myeloablative, TBI | 398 (56) | 86 (59) | |
| Myeloablative, no TBI | 119 (17) | 34 (23) | |
| RIC | 196 (27) | 25 (17) | |
| T-depletion/ATG/Campath | 290 (41) | 76 (52) | .01 |
Abbreviations: AML, acute myelogenous leukemia, ALL, acute lymphoblastic leukemia; CML, chronic myelogeneous leukemia; D, donor; NHL, non-Hodgkin’s lymphoma; R, recipient; TBI, total body irradiation; UCB, umbilical cord blood; URD, unrelated donor