Table 3.
Overall Survival | Disease Free Survival | Relapse | Non-relapse mortality | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ||||||||||||||||
Factor | Hazard Ratio |
Lower 95% CL |
Upper 95% CL |
P | Hazard Ratio |
Lower 95% CL |
Upper 95% CL |
P | Hazard Ratio |
Lower 95% CL |
Upper 95% CL |
P | Hazard Ratio |
Lower 95% CL |
Upper 95% CL |
P |
Race match | ||||||||||||||||
Matched | 1.0 | 1.0 | 1.0 | 1.0 | ||||||||||||
Mismatched | 1.0 | 0.7 | 1.3 | .86 | 0.9 | 0.6 | 1.4 | .77 | 0.8 | 0.4 | 1.5 | .48 | 1.1 | 0.7 | 1.8 | .68 |
| ||||||||||||||||
Recipient race | ||||||||||||||||
Caucasian | 1.0 | 1.0 | 1.0 | 1.0 | ||||||||||||
Ethnic minority | 1.0 | 0.7 | 1.5 | .84 | 1.1 | 0.7 | 1.7 | .74 | 1.6 | 0.8 | 3.3 | .23 | 0.8 | 0.4 | 1.5 | .51 |
| ||||||||||||||||
Donor & HLA match | ||||||||||||||||
URD well matched | 1.0 | 1.0 | 1.0 | 1.0 | ||||||||||||
URD partially matched | 1.5 | 1.0 | 2.1 | .03 | 1.4 | 0.9 | 2.1 | .14 | 1.0 | 0.5 | 2.0 | .98 | 1.3 | 0.8 | 2.2 | .27 |
URD mismatched | 1.7 | 1.2 | 2.4 | <.01 | 1.5 | 1.0 | 2.2 | .07 | 0.6 | 0.3 | 1.3 | .19 | 1.9 | 1.1 | 3.1 | .01 |
UCB 5/6 or 6/6 | 0.9 | 0.7 | 1.2 | .50 | 1.0 | 0.7 | 1.4 | .82 | 1.6 | 0.9 | 2.6 | .12 | 0.6 | 0.3 | 1.0 | .03 |
UCB 4/6 | 1.1 | 0.8 | 1.6 | .45 | 1.1 | 0.8 | 1.6 | .63 | 1.6 | 0.9 | 2.8 | .10 | 0.7 | 0.4 | 1.2 | .18 |
| ||||||||||||||||
Disease Category | ||||||||||||||||
Malignant, high risk | 2.4 | 1.9 | 3.2 | <.01 | 1.7 | 1.4 | 2.2 | <.01 | 2.0 | 1.4 | 2.7 | <.01 | 1.1 | 0.8 | 1.5 | .67 |
Malignant, standard risk | 1.6 | 1.3 | 2.1 | <.01 | 1.0 | 1.0 | 1.0 | |||||||||
Non-malignant | 1.0 | excluded | ||||||||||||||
| ||||||||||||||||
CMV | ||||||||||||||||
R+ | 1.1 | 0.9 | 1.4 | .21 | 1.1 | 0.9 | 1.3 | .50 | 0.9 | 0.7 | 1.2 | .49 | 1.1 | 0.8 | 1.6 | .41 |
R- | 1.0 | 1.0 | 1.0 | 1.0 | ||||||||||||
| ||||||||||||||||
Conditioning | ||||||||||||||||
Myeloablative | 1.0 | 0.8 | 1.2 | .90 | 0.8 | 0.6 | 1.0 | .02 | 0.6 | 0.5 | 0.9 | <.01 | 1.1 | 0.7 | 1.6 | .75 |
RIC | 1.0 | 1.0 | 1.0 | 1.0 |
Abbreviations: URD, unrelated donor; UCB, umbilical cord blood; RIC, reduced intensity conditioning