Table S4.

Adjusted mean FEV₁ responses at key time points in tiotropium and non-tiotropium groups in the combined data set

Mean (SE) AUC0–3, L	Placebo	Olodaterol 5 μg	Olodaterol 10 μg
	(Tiotropium n=90 Non-tiotropium n=333)	(Tiotropium n=86 Non-tiotropium n=327)	(Tiotropium n=95 Non-tiotropium n=326)
Week 12
Tiotropium	0.031 (0.020)	0.160 (0.020)****	0.139 (0.019)****
Non-tiotropium	−0.008 (0.010)	0.162 (0.010)****	0.166 (0.010)****
Week 24
Tiotropium	0.018 (0.020)	0.174 (0.020)****	0.123 (0.019)***
Non-tiotropium	−0.023 (0.010)	0.150 (0.010)****	0.137 (0.010)****
Week 48
Tiotropium	−0.052 (0.020)	0.148 (0.021)****	0.110 (0.019)****
Non-tiotropium	−0.032 (0.010)	0.126 (0.010)****	0.132 (0.011)****
Mean (SE) trough, L	Placebo	Olodaterol 5 μg	Olodaterol 10 μg
	(Tiotropium n=83 Non-tiotropium n=322)	(Tiotropium n=82 Non-tiotropium n=322)	(Tiotropium n=93 Non-tiotropium n=316
Week 12
Tiotropium	0.001 (0.021)	0.043 (0.021)	0.039 (0.019)
Non-tiotropium	−0.028 (0.010)	0.048 (0.010)****	0.055 (0.011)****
Week 24
Tiotropium	−0.002 (0.021)	0.050 (0.021)	0.036 (0.020)
Non-tiotropium	−0.054 (0.011)	0.030 (0.011)****	0.027 (0.011)****
Week 48
Tiotropium	−0.084 (0.021)	0.015 (0.021)**	0.017 (0.020)***
Non-tiotropium	−0.061 (0.011)	0.014 (0.011)****	0.014 (0.011)****

Notes:

^**P<0.01 versus placebo;

^***P<0.001 versus placebo;

^****P<0.0001 versus placebo.

Abbreviations: FEV₁, forced expiratory volume in 1 second; SE, standard error; AUC_0–3, area under the curve from 0–3 hours.