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. 2014 Jun 20;9(6):e100253. doi: 10.1371/journal.pone.0100253

Figure 4. Protection against R. rickettsii infection induced by surface-exposed proteins.

Figure 4

C3H/HeN mice (n = 5) were immunized three times with each rSEPs, WCA, or PBS, followed by a sublethal challenge with R. rickettsii. Five days after challenge, the mice were sacrificed and the rickettsial load in their spleens (A), livers (B), or lungs (C) was determined using R. rickettsii-specific qPCR. The rickettsial load is expressed as mean copies ± standard deviations, and the results were analyzed using T test or Wilcoxon two-sample test according to their normality and homogeneity of variance, *P<0.05 and **P<0.01. Horizontal lines indicate statistically significant differences between the WCA-immunized group and the rSEPs-immunized groups.