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. 2014 Jun 20;9(6):e99991. doi: 10.1371/journal.pone.0099991

Figure 3. Med1 ablation resulted in defects in the DE-SC niche.

Figure 3

(A) A diagram to show the location of the labial CL in mouse mandible, where DE-SCs reside. The CL is composed of OEE, IEE, SI, and SR (left). (B) Histological analyses of CL in Med1 KO and CON at 4 wk. Med1 is abundantly expressed in OEE/IEE/SR in the CL but diminished in the KO (Med1, brown signals with blue counterstaining). Histological staining shows the morphological alterations of the CL in KO (HE, red triangles). Cell proliferation is increased in OEE/IEE and IDE equivalent to transient amplifying cells (TA) in KO (PCNA staining, brown signals with blue counterstaining). Vwa2 expression in the basement membrane of OEE and IEE decreased in Med1 KO (Vwa2 brown staining with blue counterstaining). The results were reproduced in two independent experiments using two Med1 KO mice from different litters.