Table 1. Main features of toxins from the venom gland transcriptome of the tarantula O.huwena.

superfamily	signalpeptides	families	previousdata	cysteineframework	Functionidentity
I	MKASMFLAFAGLVLLFVVCYA	HWTX-I	HWTX-I	-c-c-cc-c-c- (I)	mammalian HVA Ca2+ channel initor and TTX-S Na+ channel inhibitor [34], [35]
		HWTX-III	HWTX-III	-c-c-cc-c-c- (I)	insect Na+ channel inhibitor [54]
		HWTX-IV	HWTX-IV	-c-c-cc-c-c- (I)	mammalian TTX-S Na+ channel inhibitor [51], [56]
		HWTX-V	HWTX-V	-c-c-cc-c-c- (I)	insect Ca2+ channel inhibitor [58]
		SHL	SHL-I	-c-c-cc-c-c- (I)	lectin [53]
II	MKVTLIAILTCAAVLVLHTTAA	HWTX-II	HWTX-II	-c-c-c-c-c-c- (II)
		HWTX-VII	HWTX-VII	-c-c-c-c-c-c- (II)
X	MNMKILVLVAVLCLVVSTHA	HWTX-X	HWTX-X	-c-c-cc-c-c- (I)	mammalian N-type Ca2+ channel inhibitor [36]
XI	MGIARILSAVLFLSVLFVVTFPALLSAD	HWTX-XI	HWTX-XI	-c-c-c-c-c-c- (II)	K+ channel inhibitor [37]
XIII	MKYAIVLCVIVIVVTVVRA	HWTX-XIII	HWTX-XIII	-c-c-cc-c-c- (I)
XIV	MKVVLLVCLVWMMAMMELVSC	HWTX-XIV	HWTX-XIV	-c-c-cc-c-c-c-c-c-c- (VI)
XV	MKHFASCIFSVLTVAICGVSQT	HWTX-XV	HWTX-XV	-c-c-cc-c-c-c-c- (III)
		HWTX-XXVIII		-c-c-c-c-c-c-c-c- (V)
XVI	MNTVRVTFLLVFVLAVSLGQA	HWTX-XVI	HWTX-XVI	-c-c-cc-c-c- (I)
XVII	MKIATFLGLSFLLIASYVLICEA	HWTX-XVII	HWTX-XVII	-c-c-cc-c-c-c-c- (III)
XVIII	MKLSLIIIATSLVIAVVA	HWTX-XVIII	HWTX-XVIII	-c-c-c-cc-c-c-c- (IV)
XX	MKLSNFAVVLVGILFVSVPLFA	HWTX-XX		-c-c-cc-c-c-c-c-cc-c-c- (VII)
		HWTX-XIX		-c-c-cc-c-c- (I)
XXI	MLATFIVLFVPIFRNPLCCFQCQVYG	HWTX-XXI		-c-c-c-c-c-c-c- (X)
XXII	MTWLLMVPLMLLSPLLQIAC	HWTX-XXII		-c-c-c-c- (IX)
XXIII	MIVLGGMAFSVTSMVVACVV	HWTX-XXIII		-c-c-c-c-c- (VIII)
XXIV	MVCATRRLIRLLSSSG	HWTX-XXIV		-c-c-c-c-c-c- (II)
XXV		HWTX-XXV		-c-c-c-cc-c-c- (XI)
		HWTX-XXVI		-c-c-c-c- (IX)