Table 3. B. burgdorferi in vivo-expressed candidate genes organized by functional category.
| Bbive clonea | Replicon | ORFb | Protein designation, Annotated functionc |
| Cell division | |||
| 289 | chromosome | BB0715 | FtsA cell division protein |
| Cell envelope | |||
| 15 | chromosome | BB0213 | Putative lipoprotein |
| 94 | chromosome | BB0760 | Gp37 protein |
| 175 | lp54 | BBA36 | Lipoprotein |
| 271 | lp54 | BBA57 | Lipoprotein |
| 297 | lp25 | BBE16 | BptA |
| 151 | lp28-2 | BBG01 | Putative lipoprotein |
| 267 | lp38 | BBJ34 | Putative lipoprotein |
| 269 | lp38 | BBJ51 | VlsE paralog, pseudogene |
| 162 | lp36 | BBK46 | Immunogenic protein P37, authentic frameshift |
| 77 | cp32-8, cp32-3, cp32-7, cp32-9, lp56, cp32-4,cp32-6, cp32-1 | BBL28, BBS30, BBO28, BBN28, BBQ35, BBR28, BBM28, BBP28 | Mlp lipoprotein family |
| DNA replication | |||
| 274 | chromosome | BB0111 | DnaB replicative helicase |
| 226 | chromosome | BB0632 | RecD exodeoxyribonuclease V, alpha chain |
| 152 | lp28-3 | BBH13 | RepU replication machinery |
| Energy metabolism | |||
| 62 | chromosome | BB0057 | Gap glyceraldehyde-3-phosphate dehydrogenase, type 1 |
| 34 | chromosome | BB0327 | Glycerol-3-phosphate O acyltransferase |
| 44 | chromosome | BB0368 | NAD(P)H-dependent glycerol-3-phosphate dehydrogenase |
| 47 | chromosome | BB0381 | Trehalase |
| 81 | chromosome | BB0676 | Phosphoglycolate phosphate |
| Fatty acid and phospholipid metabolism | |||
| 85 | chromosome | BB0704 | AcpP acyl carrier protein |
| Motility and chemotaxis | |||
| 14 | chromosome | BB0181 | FlgK flagellar hook-associated protein |
| 29 | chromosome | BB0293 | FlgB flagellar basal body rod |
| 290 | chromosome | BB0775 | Flagellar hook-basal body complex protein |
| 65 | chromosome | BB0551 | CheY-1 chemotaxis response regulator |
| 222 | chromosome | BB0568 | Chemotaxis response regulator protein-glutamate methylesterase |
| Prophage function | |||
| 295 | cp32-8, cp32-7, cp32-1, cp32-3, cp32-6, cp32-4 | BBL23, BBO23, BBP23, BBS23, BBM23, BBR23 | Holin BlyA family |
| Protein fate | |||
| 193 | chromosome | BB0031 | LepB signal peptidase I |
| Protein synthesis | |||
| 202 | chromosome | BB0113 | RpsR ribosomal protein S18 |
| 216, 217 | chromosome | BB0485 | RplP ribosomal protein L16 |
| 58 | chromosome | BB0495 | RpsE 30S ribosomal protein S5 |
| 59 | chromosome | BB0496 | 50S ribosomal protein L30 |
| 219 | chromosome | BB0503 | RplQ ribosomal protein L17 |
| 232 | chromosome | BB0660 | GTP-binding Era protein |
| 288 | chromosome | BB0682 | TrmU tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase |
| Regulation | |||
| 208 | chromosome | BB0379 | Protein kinase C1 inhibitor |
| 50 | chromosome | BB0420 | Hk1 histidine kinase |
| Nucleoside salvage | |||
| 148 | lp25 | BBE07 | Pfs protein, pseudogene |
| Transcription | |||
| 1 | chromosome | BB0389 | RpoB DNA-directed RNA polymerase, beta subunit |
| 287 | Chromosome | BB0607 | PcrA ATP-dependent DNA helicase |
| 84 | chromosome | BB0697 | RimM 16S rRNA processing protein |
| Transport | |||
| 204 | chromosome | BB0318 | MglA methylgalactoside ABC transporter ATP-binding protein |
| 46 | chromosome | BB0380 | MgtE Mg2+ transport protein |
| Unknown | |||
| 56 | chromosome | BB0049 | Hypothetical protein |
| 69 | chromosome | BB0063 | Pasta domain protein |
| 2 | chromosome | BB0102 | Conserved hypothetical |
| 8 | chromosome | BB0138 | Conserved hypothetical |
| 13 | chromosome | BB0176 | ATPase family associated with various cellular activities |
| 23 | chromosome | BB0265 | Conserved hypothetical |
| 212 | chromosome | BB0428 | Conserved hypothetical |
| 52, 53 | chromosome | BB0429 | Conserved hypothetical |
| 220 | chromosome | BB0504 | Conserved hypothetical |
| 67 | chromosome | BB0562 | Conserved hypothetical |
| 223 | chromosome | BB0577 | Conserved hypothetical |
| 71 | chromosome | BB0592 | Caax amino protease family |
| 73 | chromosome | BB0619 | DHH family phosphoesterase function |
| 96 | chromosome | BB0799 | Conserved hypothetical |
| 240 | cp26 | BBB27 | Unknown essential protein |
| 145, 146 | lp25 | BBE0036 | Hypothetical protein |
| 147 | lp25 | BBE01 | Conserved hypothetical |
| 265, 266 | lp38 | BBJ30 | Conserved hypothetical |
| 171 | lp38 | BBJ36 | Conserved hypothetical |
| 75,173 | lp38 | BBJ46 | Conserved hypothetical |
| 129, 136, 296 | cp32-8, cp32-1, cp32-7, lp56, cp32-9 | BBL41, BBP40, BBO42, BBQ48, BBN41 | Conserved hypothetical |
| 130, 249 | cp32-8, cp32-1, cp32-6 | BBL42, BBP41, BBM41 | Conserved hypothetical |
| 117, 177 | cp32-6, lp56, cp32-9, cp32-8, cp32-3, cp32-1, cp32-4 | BBM18, BBQ25, BBN18, BBL18, BBS18,BBP18, BBR18 | Conserved hypothetical |
| 182, 183 | lp56 | BBQ41 | PF-49 protein |
| 188 | lp56 | BBQ84.1 | Conserved hypothetical |
| 189 | lp56, lp28-3, lp17 | BBQ89, BBH01, BBD01 | Conserved domain protein |
| 244 | cp32-4, cp32-3, cp32-6, p56, cp32-8, cp32-9 | BBR05, BBN05, BBM05, BBQ12, BBL05, BBO05, BBP05 | Lyme disease protein of unknown function |
a
In some cases two or more Bbive clones shared overlapping, non-identical sequence, as indicated by multiple Bbive clone numbers.
b
ORF, open reading frame that maps just downstream and in the same orientation to the Bbive sequence.
c
Annotation described by Fraser et al. [45].